Bryostatin 1 Plus Cladribine in Treating Patients With Relapsed Chronic Lymphocytic Leukemia

DISEASE CHARACTERISTICS:

* Diagnosis of relapsed chronic lymphocytic leukemia

  * Intermediate- or high-risk (stage I-IV) disease
* Intermediate-risk patients must have active disease, defined by at least 1 of the following criteria:

  * Presence of any 1 of the following disease-related B symptoms:

    * 10% or more loss of body weight within the past 6 months
    * Extreme fatigue
    * Fever greater than 100 degrees Fahrenheit without evidence of infection
    * Night sweats
  * Massive (greater than 6 cm below left costal margin) or progressive splenomegaly
  * Massive (greater than 10 cm in longest diameter) or progressive lymphadenopathy
  * Progressive lymphocytosis with an increase of more than 50% over a 2-month period or anticipated doubling time of less than 12 months
  * Progressive bone marrow failure as manifested by the development or worsening of anemia and/or thrombocytopenia
  * Autoimmune anemia and/or thrombocytopenia poorly responsive to corticosteroids
* Failed 1-2 prior front-line regimens
* Failed prior fludarabine
* Ineligible for any known treatment of higher potential efficacy

PATIENT CHARACTERISTICS:

Age:

* 18 and over

Performance status:

* Zubrod 0-2

Life expectancy:

* At least 12 weeks

Hematopoietic:

* See Disease Characteristics
* Absolute neutrophil count at least 1,000/mm\^3
* Platelet count at least 50,000/mm\^3

Hepatic:

* Bilirubin less than 1.5 mg/dL
* Transaminases less than 2.5 times normal

Renal:

* Creatinine less than 1.5 mg/dL OR
* Creatinine clearance at least 60 mL/min

Cardiovascular:

* No history of severe coronary artery disease, cardiomyopathy, uncontrolled congestive heart failure, or arrhythmias

Neurologic:

* No prior drug-related neurotoxicity
* No other neurologic disorder

Other:

* Not pregnant or nursing
* Fertile patients must use effective barrier or non-hormonal contraception during and for 2 months after study participation
* No HIV infection
* No AIDS

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* No prior bone marrow transplantation

Chemotherapy:

* See Disease Characteristics
* At least 4 weeks since prior chemotherapy (8 weeks for mitomycin or nitrosoureas) and recovered

Endocrine therapy:

* See Disease Characteristics
* No concurrent steroids
* No concurrent hormonal contraceptives

Radiotherapy:

* At least 4 weeks since prior radiotherapy and recovered

Surgery:

* Not specified

Other:

* No other concurrent therapy