Clinical trial · Interventional

Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors

Photodynamic Therapy For Childhood Brain Tumors, A Phase I Study

NCT00002647CI-TRIAL-00012256unknownPhase 1ClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

RATIONALE: Photodynamic therapy uses light and photosensitizing drugs to kill tumor cells and may be an effective treatment for refractory brain tumors. PURPOSE: This phase I trial is studying the side effects and best dose of photodynamic therapy using porfimer sodium in treating patients with refractory brain tumors, including astrocytoma, ependymoma, and medulloblastoma.

Conditions

Conditions (2)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Brain and Central Nervous System Tumors	—	UNRESOLVED	—
Metastatic Cancer	Malignant Neoplasm	CURATED_BROADER	0.78

Interventions

Interventions (2)

Intervention	Type	Mapped drug	Match
conventional surgery	Procedure	—	UNRESOLVED
verteporfin	Drug	Verteporfin	ALIAS

Eligibility

Eligibility (as posted)

Sex: All
Minimum age: 3 Years
Maximum age: 70 Years

Show eligibility criteria text

DISEASE CHARACTERISTICS:

* Diagnosis of supratentorial or infratentorial brain tumor

  * Localized, non-disseminated
  * Primary tumor or solitary metastasis
  * Recurrent or progressive
  * Unresectable
  * Negative CSF
* Must have failed standard therapy including radiotherapy
* Measurable disease as evidenced by CT scan or MRI

  * Single or multiple masses accessible to light administration

PATIENT CHARACTERISTICS:

Age:

* 3 to 70

Performance status:

* Not specified

Life expectancy:

* At least 2 months

Hematopoietic:

* Absolute neutrophil count at least 1,000/mm3
* May transfuse platelets

Hepatic:

* PT and PTT normal

Renal:

* Not specified

Other:

* Not pregnant

PRIOR CONCURRENT THERAPY:

Biologic therapy:

* Not specified

Chemotherapy:

* At least 6 weeks since prior chemotherapy

Endocrine therapy:

* Not specified

Radiotherapy:

* See Disease Characteristics
* No prior brachytherapy

Surgery:

* See Disease Characteristics

Other:

* No other concurrent antitumor therapy

References

Publications (1)

BACKGROUNDSchmidt MH, Bajic DM, Reichert KW 2nd, Martin TS, Meyer GA, Whelan HT. Light-emitting diodes as a light source for intraoperative photodynamic therapy. Neurosurgery. 1996 Mar;38(3):552-6; discussion 556-7. doi: 10.1097/00006123-199603000-00025. PMID 8837808

Registry

Dates and enrollment

Start: May 1, 1994
Primary completion: —
Completion: —
First posted: Jan 27, 2003
Last update posted: Sep 20, 2013
Enrollment: 24 (estimated)
Lead sponsor: Medical College of Wisconsin OTHER
Keywords: recurrent adult brain tumor, tumors metastatic to brain, recurrent childhood brain stem glioma, recurrent childhood anaplastic astrocytoma, recurrent childhood anaplastic oligoastrocytoma, recurrent childhood anaplastic oligodendroglioma, recurrent childhood cerebellar astrocytoma, recurrent childhood cerebral astrocytoma, recurrent childhood diffuse astrocytoma, recurrent childhood fibrillary astrocytoma, recurrent childhood gemistocytic astrocytoma, recurrent childhood giant cell glioblastoma, recurrent childhood glioblastoma, recurrent childhood gliomatosis cerebri, recurrent childhood gliosarcoma, recurrent childhood oligodendroglioma, recurrent childhood pilocytic astrocytoma, recurrent childhood pilomyxoid astrocytoma, recurrent childhood pleomorphic xanthoastrocytoma, recurrent childhood protoplasmic astrocytoma, recurrent childhood subependymal giant cell astrocytoma, recurrent childhood visual pathway and hypothalamic glioma, recurrent childhood visual pathway glioma, recurrent childhood pineoblastoma, recurrent childhood supratentorial primitive neuroectodermal tumor, recurrent childhood medulloblastoma, recurrent childhood ependymoma, recurrent childhood brain tumor, adult anaplastic astrocytoma, adult anaplastic ependymoma, adult anaplastic meningioma, adult anaplastic oligodendroglioma, adult brain stem glioma, adult central nervous system germ cell tumor, adult choroid plexus tumor, adult craniopharyngioma, adult diffuse astrocytoma, adult ependymoblastoma, adult ependymoma, adult giant cell glioblastoma, adult glioblastoma, adult gliosarcoma, adult medulloblastoma, meningeal melanocytoma, adult meningeal hemangiopericytoma, adult oligodendroglioma, adult papillary meningioma, adult pilocytic astrocytoma, adult pineal gland astrocytoma, adult pineoblastoma, adult pineocytoma, adult subependymal giant cell astrocytoma, adult subependymoma, adult supratentorial primitive neuroectodermal tumor (PNET), childhood grade I meningioma, childhood grade II meningioma, childhood grade III meningioma, adult grade III meningioma, childhood central nervous system germ cell tumor, childhood choroid plexus tumor, childhood craniopharyngioma, childhood infratentorial ependymoma, childhood supratentorial ependymoma, childhood low-grade cerebral astrocytoma, childhood high-grade cerebral astrocytoma

Brief summary (as posted)

Conditions (2)

Interventions (2)

Eligibility (as posted)

Publications (1)

Locations by country (2)