Clinical trial · Interventional
Homoharringtonine and Interferon Alfa in Treating Patients With Chronic Myelogenous Leukemia
PHASE II STUDY OF SIMULTANEOUS HOMOHARRINGTONINE (NSC 141633) AND ALPHA INTERFERON (IFN-A) THERAPY IN CHRONIC MYELOGENOUS LEUKEMIA (CML)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Phase II trial to study the effectiveness of homoharringtonine and interferon alfa in treating patients with chronic myelogenous leukemia. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Combining chemotherapy with interferon alfa may kill more cancer cells.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Leukemia | Leukemia | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| omacetaxine mepesuccinate | Drug | Omacetaxine Mepesuccinate | ALIAS |
| recombinant interferon alfa | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Arm I
- description
- Single-Agent Chemotherapy plus Biological Response Modifier Therapy. Homoharringtonine, HH, NSC-141633; plus Interferon alfa (Schering), IFN-A, NSC-377523.
- interventionNames
- Biological: recombinant interferon alfa
- Drug: omacetaxine mepesuccinate
Primary outcomes (0)
[]Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 15 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Chronic myelogenous leukemia (CML) in chronic phase * Clonal evolution (i.e., the presence of clones other than the Ph chromosome) allowed Ph chromosome variants or complex Ph chromosome translocations are not considered disease acceleration * Ineligible for known therapy of higher efficacy or priority * Allogeneic bone marrow transplantation should be considered priority therapy for CML patients with a matched related donor * No blastic phase CML (30% or more blasts in peripheral blood or bone marrow) * No accelerated phase CML, defined as any of the following: 15% or more peripheral or marrow blasts or 30% or more blasts and promyelocytes 20% or more peripheral or marrow basophils * Thrombocytopenia (platelets less than 100,000) unrelated to therapy * Documented extramedullary disease outside of liver or spleen PATIENT CHARACTERISTICS: * Age: 15 and over * Performance status: Zubrod 0-2 * Life expectancy: Sufficient to fully evaluate the effects of 2 courses of therapy * Bilirubin no greater than 2.0 mg/dL * SGOT less than 300 * Creatinine less than 2.0 mg/dL OR creatinine clearance at least 60 mL/min * No severe heart disease (class III/IV) * No pregnant or nursing women * Effective contraception required of fertile women PRIOR CONCURRENT THERAPY: * No prior interferon alpha * At least 2 weeks since antileukemic therapy, with recovery required * Patients who received hydroxyurea within the past 2 weeks and have WBC greater than 50,000 may enter protocol after discussion with the primary investigator
References
Publications (0)
Data not yet available