Clinical trial · Interventional
Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors
Phase II Pre-Irradiation Chemotherapy for Central Nervous System Germ Cell Malignancies
NCT00002472CI-TRIAL-00004565completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of cisplatin and etoposide in treating patients with CNS tumors.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain and Central Nervous System Tumors | — | UNRESOLVED | — |
| Extragonadal Germ Cell Tumor | Extragonadal Germ Cell Tumor | ONTOLOGY_EXACT | 0.98 |
| Pediatric Germ Cell Tumor | Childhood Germ Cell Tumor | ALIAS | 0.90 |
Interventions
Interventions (5)
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Response rate
- measure
- Survival
- measure
- Endocrine and cognitive function
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 3 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Histologically proven CNS germ cell tumor of 1 of the following subtypes: * CNS germinoma * Immature teratoma * Embryonal cell carcinoma * Yolk sac tumor * Endodermal sinus tumor * Choriocarcinoma OR * Pineal or suprasellar mass associated with elevated CSF alpha fetoprotein or beta-human chorionic gonadotropin allowed * Patients 18 years and over with localized pure germinomas ineligible * Evaluable CT or MRI of brain and/or spinal cord required PATIENT CHARACTERISTICS: Age: * 3 and over Hematopoietic: * Age 18 and over: * WBC at least 4,000/mm\^3 * Platelet count at least 100,000/mm\^3 * Under age 18: * Absolute neutrophil count at least 1,000/mm\^3 * Platelet count at least 100,000/mm\^3 Hepatic: * Not specified Renal: * Creatinine no greater than 0.3 mg/dL above upper limit of normal for age Other: * No uncontrolled infection * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * No prior chemotherapy for CNS germ cell tumor Endocrine therapy: * Concurrent corticosteroids allowed except as antiemetics Radiotherapy: * No prior cranial or spinal radiotherapy Surgery: * Not specified
References
Publications (0)
Data not yet available
No reference posted for this study.