A Comparison of DOX-SL Versus Adriamycin Plus Bleomycin Plus Vincristine in the Treatment of Severe AIDS-Related Kaposi's Sarcoma

Inclusion Criteria

Concurrent Medication:

Allowed:

* Prophylaxis for PCP, cryptococcal, and herpes infections, and antiretroviral therapy (e.g., AZT, ddC, ddI) provided these doses have been stable for at least 1 month.
* Therapy for tuberculosis, fungal, and herpes infections except with potentially myelotoxic chemotherapy.
* Foscarnet for new episodes of cytomegalovirus infection.
* Colony-stimulating factors and erythropoietin.

Patients must have:

* Biopsy-proven, progressive, AIDS-related Kaposi's sarcoma, with any of the following:
* At least 25 mucocutaneous lesions.
* Ten or more new lesions in the prior month.
* Documented visceral disease with at least two accessible cutaneous lesions.
* Two accessible cutaneous lesions with edema.
* Documented anti-HIV antibody.
* No active opportunistic infection with mycobacteria, cytomegalovirus, toxoplasma, Pneumocystis carinii, or other microorganisms (if under treatment with myelotoxic drugs).
* Life expectancy \> 4 months.

NOTE:

* Patients who respond to therapy on this protocol, as well as those who fail the ABV combination, are eligible to enter the Liposome Technology open trial using DOX-SL alone.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

* Clinically significant cardiac, hepatic, or renal disease.
* Peripheral neuropathy, signs of moderate to severe sensory loss, or moderate to marked motor loss.
* Inability to comply with the study.

Concurrent Medication:

Excluded:

* Other cytotoxic chemotherapy.
* Ganciclovir.

Patients with the following prior conditions are excluded:

* Prior neoplasms treated with extensive chemotherapy that, in the investigator's opinion, has led to irreversibly compromised bone marrow function.
* History of idiosyncratic or allergic reaction to bleomycin or vincristine.

Prior Medication:

Excluded:

* Prior anthracycline therapy.
* Cytotoxic chemotherapy or interferon treatment within the past 4 weeks.

Prior Treatment:

Excluded:

* Radiation or electron beam therapy within the past 3 weeks.