Topical Use of 4,4'-Dihydroxybenzophenone-2,4-Dinitrophenylhydrazone (A-007) in the Treatment of Advanced Malignancies Including Kaposi's Sarcoma and Lymphoproliferative Disorders

Inclusion Criteria

Concurrent Medication:

Allowed:

* Maintenance antihormones, hormones, and glucocorticoids.

Patients must have:

* Histologically proven metastatic cancer including Kaposi's sarcoma and lymphoproliferative disorders to the skin or cutaneous sites. NOTE:
* Primary basal or squamous cell cancer of the skin is allowed.
* Failed both primary and secondary chemotherapy and/or immunotherapy protocols.
* Measurable skin or cutaneous lesions. 4 Life expectancy of at least 20 weeks.

Prior Medication:

Required:

* Prior therapy for cutaneous lesions from Kaposi's sarcoma or lymphoproliferative disorders.

Allowed:

* Prior maintenance steroids and hormone/antihormone therapy.

Exclusion Criteria

Co-existing Condition:

Patients with the following symptoms or conditions are excluded:

* Active infections other than medically stable HIV infection.
* Active congestive heart failure, any persistent arrhythmia or transient serious arrhythmia (ventricular tachycardia, sinoatrial arrest, etc.), or progressive cardiomyopathy.
* Unstable blood pressure.
* Seizures or other CNS disorders.
* Severe unstable diabetes mellitus.
* Coagulopathies.
* Thrombotic disease.
* Any other medical conditions that would prevent completion of study or produce significant risk to patient.

Concurrent Medication:

Excluded:

* Concomitant chemotherapy or immunotherapy.
* Ongoing corticosteroid therapy (unless maintenance).

Patients with the following prior conditions are excluded:

* History of active cardiopulmonary or respiratory disease.
* History of sun hypersensitivity and photosensitive dermatoses.
* History of allergy or hypersensitivity to cosmetics, toiletries, or other dermatological products.