Clinical trial · Interventional
Dapsone 100 Mg Versus 50 as Primary Prophylaxis for Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS-Related Complex (ARC)
NCT00002043CI-TRIAL-00000085completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To determine which of 2 doses of dapsone is effective prophylaxis for Pneumocystis carinii pneumonia (PCP) in patients with oral thrush or hairy leukoplakia and less than 400 CD4 lymphocytes per mm3. To determine whether the long-term toxicities associated with daily dapsone in this population are tolerable.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| HIV Infections | — | UNRESOLVED | — |
| Pneumonia, Pneumocystis Carinii | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dapsone | Drug | — | UNRESOLVED |
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
Show eligibility criteria text
Inclusion Criteria The patient must have HIV positive antibody test and presence of oral thrush or hairy leukoplakia. * Patient must be willing and able to sign informed consent. Exclusion Criteria Co-existing Condition: Patients with the following are excluded: * Prior Pneumocystis carinii pneumonia (PCP) or AIDS-defining condition. * Prophylaxis for PCP in preceding 3 months. * Absence of detectable glucose-6-phosphate dehydrogenase (G6PD) activity. * Prior type I hypersensitivity (anaphylaxis, urticaria, angioedema) or exfoliative dermatitis during treatment with dapsone. * History of poor compliance. Concurrent Medication: Excluded: * Zidovudine (AZT). Patients with the following are excluded: * Prior Pneumocystis carinii pneumonia (PCP) or AIDS-defining condition. * Prophylaxis for PCP in preceding 3 months. * Absence of detectable glucose-6-phosphate dehydrogenase (G6PD) activity. * Concurrent or prior therapy with zidovudine (AZT). * Prior type I hypersensitivity (anaphylaxis, urticaria, angioedema) or exfoliative dermatitis during treatment with dapsone. * History of poor compliance. Prior Medication: Excluded: * Zidovudine (AZT).
References
Publications (0)
Data not yet available
No reference posted for this study.