Clinical trial · Interventional
Diagnostic Effectiveness of Virtual Bronchoscopy
Diagnostic Efficacy of Virtual Bronchoscopy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will evaluate a new technique for examining the air passages of the lungs called "virtual bronchoscopy." It involves using computed tomography (CT) images of the chest to generate a 3-dimensional model of the walls of the trachea and bronchi (airway passages). This non-invasive method lets doctors see small masses and areas of narrowing in the passages without having to do surgery or pass a tube through them. Patients with diseases of the air passages who are enrolled in an NIH clinical trial may participate in this study, which requires having a CT scan. The patient lies on a table that slowly slides into a hole in a donut-shaped X-ray machine (the scanner). Patients may have to hold their breath several times during the procedure. Some patients may be given an injection of a contrast agent through a catheter (thin tube) placed in an arm vein to improve visibility of abnormalities. Patients may also be asked to breathe oxygen through nasal prongs to allow them to hold their breath longer. The procedure usually takes 15 to 20 minutes.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bronchogenic Carcinoma | Bronchogenic Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Chronic Granulomatous Disease | — | UNRESOLVED | — |
| Job's Syndrome | — | UNRESOLVED | — |
| Mycobacterium Infection | — | UNRESOLVED | — |
| Wegener's Granulomatosis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| virtual bronchoscopy | Device | — | UNRESOLVED |
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Patients with Wegener's granulomatosis who are scheduled for fiberoptic bronchoscopy. Patients with cavitary lung diseases who are enrolled in protocols studying patients with Wegener's granulomatosis, chronic granulomatosis disease, host immune defects, mycobacterial infections, and Job's syndrome. Patients with bronchogenic carcinoma, other thoracic malignancies, or metastatic disease to the thorax. Patients will be selected from Clinical Center inpatient and outpatient population based on a clinical suspicion of pulmonary, mediastinal or bronchial disease, and are to have medically indicated chest CT. Written informed consent will be obtained from all patients and studies will only be done with the permission of the patient's attending physician. Patients will be drawn from the following protocols: 92-I-0186 93-I-0119 94-I-0149 95-I-0091 90-I-0086 76-I-0023 92-I-0255 93-I-0172 95-I-0177 Subjects must not be pregnant and be able to hold their breath for required periods of time.
References
Publications (3)
- BACKGROUNDSummers RM, Feng DH, Holland SM, Sneller MC, Shelhamer JH. Virtual bronchoscopy: segmentation method for real-time display. Radiology. 1996 Sep;200(3):857-62. doi: 10.1148/radiology.200.3.8756944. PMID 8756944
- BACKGROUNDSummers RM. Navigational aids for real-time virtual bronchoscopy. AJR Am J Roentgenol. 1997 May;168(5):1165-70. doi: 10.2214/ajr.168.5.9129406. PMID 9129406
- BACKGROUNDSummers RM, Shaw DJ, Shelhamer JH. CT virtual bronchoscopy of simulated endobronchial lesions: effect of scanning, reconstruction, and display settings and potential pitfalls. AJR Am J Roentgenol. 1998 Apr;170(4):947-50. doi: 10.2214/ajr.170.4.9530041. No abstract available. PMID 9530041