A Study of Tumor Necrosis Factor and Human Interferon-gamma in Patients With AIDS Related Complex

Inclusion Criteria

Patients who have a primary diagnosis of AIDS related complex (ARC) including lymphadenopathy syndrome (LAS), who are positive for HIV antibody, have a minimum life expectancy of 3 months, and have one or more of the following symptoms for = or \> 30 days:

* Fever.
* Night sweats.
* Fatigue.
* Oral thrush.
* Hairy leukoplakia.
* Diarrhea.
* Weight loss \< 10 percent.
* Patients must be able to sign a written informed consent form, which must be obtained prior to treatment.

Concurrent Medication:

Allowed:

* Acetaminophen for temperature rise of \> 38.5 degrees C - 650 mg by mouth every 4 hours on an as needed basis.

Severe rigors may be treated (or prevented) with meperidine 50 mg IV on an as needed basis in the absence of systolic hypotension \< 80 mm Hg.

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Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

* Clinically significant cardiac disease - New York Heart Association Class II, III, or IV.
* Hemorrhagic diathesis (including hemophilia) or active bleeding disorder (e.g., genitourinary, gastrointestinal).
* Clinically apparent vascular disease (including a prior history of pulmonary embolus, deep venous thrombosis, or peripheral arterial occlusive disease).

Concurrent Medication:

Excluded:

* Medications required for the treatment of active cardiac disease including cardiac glycosides, antiarrhythmics and antianginal agents.
* Anticoagulants.
* Thrombolytic agents.
* Nonsteroidal anti-inflammatory drugs.
* Ongoing therapy with vasodilators.
* Aspirin.
* Corticosteroids.
* Antihistamines.
* Barbiturates.
* Excluded within 4 weeks of study entry:
* Antiviral chemotherapy.
* Immunotherapy.
* Excluded within 12 weeks of study entry:
* Suramin.

Patients with the following are excluded:

* AIDS-associated opportunistic infection.
* Lipoprotein disorders.
* Hemophilia.

Prior Medication:

Excluded:

* Interferon gamma.
* Tumor necrosis factor.