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Benzamil-induced cytotoxicity in non-small cell lung cancer is associated with mitochondrial damage, mitochondrial elongation, and altered XIAP signaling.

Tzu-Cheng Chien, Jia-Yun Chen, Ko-Hsuan Lo, Yi-Wei Fang, Chia-Chi Tsai, Xu-Chen Liu, Chian-Ju Hsu, Jen-Jui Chang, You-Syuan Lou, Yi-Hsuan Yin, Chih-Cheng Cheng, Hsin-Hsien Yu, Bor-Chyuan Su

Journal of pharmacological sciencesNov 1, 2026PMID 42810781doi:10.1016/j.jphs.2026.09.004 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Oct 1, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20261001-000001
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Despite newly introduced treatment options, the 5-year survival rate for non-small cell lung cancer (NSCLC) remains below 20%, indicating a remaining need for new treatment strategies. Benzamil (BZ) has demonstrated inhibitory effects on brain tumors and osteosarcoma; however, its effects on NSCLC…

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