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SRSF3 plays a key role in liver cancer sex disparity by facilitating hepatocyte expression of ERα and FOXA.

Lulu Yu, Masahiko Ajiro, Vladimir Majerciak, Alexei Lobanov, Yafeng He, Maggie Cam, Baktiar Karim, Deanna Gotte, Chuxia Deng, Keji Zhao, Douglas R Lowy, Nicholas J G Webster, Zhi-Ming Zheng

Proceedings of the National Academy of Sciences of the United States of AmericaOct 6, 2026PMID 42809395doi:10.1073/pnas.2536317123 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260930-000001
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SRSF3 (SRp20) is an essential RNA splicing factor. By conditional knockout (KO) of Srsf3, we found Srsf3 at its physiological level plays a tumor-suppressive role in mouse liver carcinogenesis. Srsf3 KO in hepatocytes disrupted sex disparity in the development of DEN-induced liver cancer and…

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