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STC2 promotes cisplatin resistance through metabolic reprogramming and lactylation-mediated epigenetic regulation in cervical cancer.

Shanshan Jin, Dongqin Gao, Yaling Xiahou, Junxia Tao, Danna Jia, Lijuan Huang, Zhizhen Liu, Shulin Hou, Jun Xie, Huimin Lv

Acta biochimica et biophysica SinicaSep 29, 2026PMID 42809369doi:10.3724/abbs.2026169 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260930-000001
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Cervical cancer (CC) is a major threat to women's health globally, and the development of cisplatin (DDP) resistance is a key factor leading to treatment failure. Prior research from our group has demonstrated the significant involvement of stanniocalcin-2 (STC2) in mediating DDP-resistance in CC.…

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