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A candidate PPARγ to GPX4 axis in ferroptosis suppression and platinum resistance in bladder cancer: evidence appraisal and a testable research agenda.

Shenjuan Li, Hongwei Peng, Gang Li, Ziyu Wan, Mengxue Yu, Sheng Tu, Fangjin Chen, Lingao Ju, Gang Wang, Kaiyu Qian, Yu Xiao, Zilin Xu

Journal of CancerJan 1, 2026PMID 42807712doi:10.7150/jca.139186 PMC13617410Journal ArticleReviewpubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

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Cytotoxic chemotherapy no longer holds an uncontested place in the treatment of muscle-invasive bladder cancer, although platinum-based therapy remains relevant in selected perioperative, bladder-preservation, upper-tract, and salvage settings. Mechanisms of platinum resistance therefore retain…

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