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Ferroptosis regulates metabolic inflammation-driven tumorigenesis in obesity-related gastric cancer.

Mizuki Tanabe, Kaname Uno, Toru Tamahara, Naoki Asano, Seizo Koshiba, Keisuke Kusano, Koya Ogasawara, Yumiko Kaise, Masahiro Saito, Tomoyuki Koike, Ritsuko Shimizu, Atsushi Masamune

Cellular and molecular gastroenterology and hepatologySep 28, 2026PMID 42805585doi:10.1016/j.jcmgh.2026.101900 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260930-000001
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BACKGROUND AND AIMS: The incidence of gastric cardia adenocarcinoma (GCA) has increased with increasing prevalence of metabolic syndrome (MetS). Peroxisome proliferator-activated receptor-delta (PPAR-δ) emerged as a key target in MetS and carcinogenesis. We aimed to elucidate its role in GCA…

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