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Integrated reverse network toxicology and experimental validation identify PTP4A3 as a key target of Benzo[a]pyrene in prostate cancer.

Shiwang Yuan, Jiang Shi, Lin Jiang, Wei Li, Peng Chen, Wei Gu, Jun Qiao, Xiong Zou, Guangshi Du, Tao Li

Chemico-biological interactionsSep 28, 2026PMID 42805285doi:10.1016/j.cbi.2026.112351 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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Prostate cancer (PCa), a leading cause of cancer morbidity in males globally, is closely related to genetic susceptibility and environmental exposure, which is difficult to clarify by traditional methods. To elucidate this mechanism, we adopted an integrated strategy that combined multi-omics…

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