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PCK1 promotes gastric cancer progression by activating the SRC1-JAK1-STAT3 signaling axis.

Jiao Nie, Tian Li, Xingyu Yang, Wenxin Bi, Weisheng Lu, Jinming Zhang, Chunmei Li, Yuqing Guan, Xiang Peng, Ping Wang, Feng Liu, Ruling Shen, Chenglin Li, Chao Du

Translational oncologySep 28, 2026PMID 42805114doi:10.1016/j.tranon.2026.103052 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260930-000001
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BACKGROUND: Phosphoenolpyruvate carboxykinase 1 (PCK1) has been shown to have signalling functions beyond gluconeogenesis. However, its role in gastric cancer is unclear. OBJECTIVE: To determine the clinical significance, biological function and molecular mechanism of PCK1 in gastric…

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