Publication
Identification of Crocin I as a positive modulator of GSTP1 with potential relevance to prostate cancer.
Hao Qin, YuanYuan Wang, Yukai Yang, Haihong Fang, Yangbiao Li, Yuxiu Yang, Yinhua Xiong, Lin Zhang
Journal of enzyme inhibition and medicinal chemistryDec 1, 2026PMID 42803268doi:10.1080/14756366.2026.2736806 Journal ArticlepubmedProvenance
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- PubMed
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- Sep 29, 2026
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- ING-PUBMED-20260929-000001
Abstract
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Glutathione S-transferase Pi 1 (GSTP1) is frequently silenced in prostate adenocarcinoma (PRAD), yet whether its residual catalytic activity can be chemically enhanced is largely unexplored. Here, we identify Crocin I as a positive modulator of GSTP1 through structure-based screening, biophysical…
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- cancerMalignant Prostate Neoplasmdictionary0.60
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