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Hypertemperature-Detonated Biomimetic Semiconductor Stromal Bombs for Enhanced Immunotherapy in Pancreatic Cancer.

Chengke Xie, Houjuan Zhu, Jianfan Wen, Yichao Mo, Wanwan Wang, Chui Yu Chan, Xinquan Lin, Xiaoxiao Huang, Ge Li, Yongding Wu, Xiaotong Fan, Zheng Jie, Maolin Yan, Zhiyuan Li, Zuwei Wang, Jerry Zhi Xiong Heng, Karen Yuanting Tang, Yifeng Tian, Enyi Ye, Loh Xian Jun, Zibiao Li, Chengyu Liao, Shi Chen

Advanced materials (Deerfield Beach, Fla.)Sep 28, 2026PMID 42802701doi:10.1002/adma.202523468 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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Pancreatic ductal adenocarcinoma (PDAC) is characterized by "copper avidity", which easily leads to the dysregulation of copper ion homeostasis. It is possible to develop targeted nanodrugs that selectively kill cancer cells via cuproptosis. However, the dense stroma of PDAC acts as an airtight…

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