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Does Positive Margin in Secondary Tumors at Radical Prostatectomy Predict Biochemical Recurrence in Multifocal Prostate Cancer?

Nikunj B Shah, Angelica Menendez, Sanoj Punnen, Adam D Williams, Radka Stoyanova, Alan Pollack, Bruno Nahar, Dipen J Parekh, Mark L Gonzalgo, Oleksandr N Kryvenko

The American journal of surgical pathologySep 28, 2026PMID 42802667doi:10.1097/PAS.0000000000002622 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 29, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
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Positive surgical margin (M+), higher-grade group (GG), extraprostatic extension (EPE), seminal vesicle invasion (SV+), and tumor volume (TV) are among the factors at radical prostatectomy (RP) demonstrating strong independent correlations with subsequent biochemical recurrence (BCR). However, the…

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