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Insulin-Like Growth Factor Axis and Survival in Metastatic Hormone-Sensitive Prostate Cancer: Post-Hoc Analysis From the ENZAMET Phase 3 Trial.

Michael A Cilento, Hui-Ming Lin, Nicole Yeung, Rachel M N Kim, Neil Portman, Martin R Stockler, Andrew J Martin, Vinod Subhash, Sonia Yip, Lisa M Butler, Ian C Marschner, Peter J Meikle, Arun A Azad, Ian D Davis, Lisa G Horvath, Christopher J Sweeney

The ProstateSep 27, 2026PMID 42801727doi:10.1002/pros.70245 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 29, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260929-000001
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BACKGROUND: A higher ratio of IGF-1:IGF binding protein 1 (IGFBP1) was associated with improved prognosis in the CHAARTED trial of docetaxel in participants with metastatic hormone-sensitive prostate cancer (mHSPC). The ENZAMET trial demonstrated the survival benefit of adding enzalutamide to…

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