Publication
Degrading GPX4 via Biomimetic Nanoparticle-Mediated In Situ Synthesis of Deep-Learning-Designed Binder-Degron Chimeras for Prostate Cancer Therapy.
Si-Han Zhang, Ye An, Na Zeng, Mei-Cheng Liu, Jian-Xuan Sun, Xi Gong, Jin-Zhou Xu, Shao-Gang Wang, Qi-Dong Xia
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Sep 27, 2026PMID 42801636doi:10.1002/advs.77932 PMC13616326Journal ArticlepubmedProvenance
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- PubMed
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- Sep 29, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260929-000001
Abstract
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Glutathione peroxidase 4 (GPX4) is a central guardian against ferroptosis and a critical therapeutic target for castration-resistant prostate cancer (CRPC). However, traditional GPX4 inhibitors are often limited by irreversible covalent binding and systemic toxicity. Here, we utilized the deep…
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- cancerMalignant Prostate Neoplasmdictionary0.60
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