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Digital PCR for Detecting Loss of BAP1 and MTAP in Pleural Fluids of Mesothelioma Patients: Perspectives in the Diagnosis.

Giulia Rosini, Greta Alì, Rossella Bruno, Monica Cipollini, Rudy Foddis, Alessandra Celi, Roberto Silvestri, Filomena Rea, Vittorio Aprile, Marco Lucchi, Federica Gemignani, Stefano Landi

Pathology internationalSep 1, 2026PMID 42801547doi:10.1111/pin.70172 PMC13616427Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

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Pleural mesothelioma (PM) often presents loss of BAP1 and MTAP genes. Digital PCR (dPCR) can accurately measure gene copy numbers (CNs). We hypothesized that cell-free DNA (cfDNA) extracted from the supernatant of pleural fluids (SPFs) could allow an efficient detection of these genetic events.…

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