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A plasma derived hypoxia signature predicts benefit from hypoxia-modifying radiotherapy and reveals dynamic humoral immune modulation in bladder cancer.

C Guerrero Quiles, H Abumanhal-Masarweh, J G Abalos, T Lodhi, D Sanchez-Martinez, K Reeves, Nicholas D James, Emma Hall, Robert A Huddart, Nuria Porta, P Hoskin, L V Biolatti, M Hadjidemetriou, C M West, A Choudhury

British journal of cancerSep 26, 2026PMID 42800813doi:10.1038/s41416-026-03603-x Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 29, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260929-000001
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INTRODUCTION: Hypoxia is a hallmark of solid tumours and drives radioresistance, yet no hypoxia biomarkers are used clinically. We explored nanoproteomics to identify a plasma protein signature for longitudinal non-invasive hypoxia monitoring. METHODS: Twenty-three bladder cancer patients (T2-T3b)…

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