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Definitive Chemoradiotherapy Versus Total Laryngectomy Followed by Postoperative Therapy in Selected T3-T4a N0-N1 Laryngeal Cancer: Comparative Outcomes.

Ozlem Ozkaya Akagunduz, Tugce Bozkurt Vardar, Ecem Yigit, Gozde Yazici, Fethiye Odaci, Mervenur Bay, Kerem Ozturk, Mustafa Cengiz, Oguz Kuscu, Gokhan Ozyigit, Mustafa Esassolak

CancersSep 14, 2026PMID 42794932doi:10.3390/cancers18182966 PMC13604556Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

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Background/Objectives: Management of locally advanced laryngeal squamous cell carcinoma remains controversial. This study compared definitive chemoradiotherapy (CRT) with total laryngectomy followed by postoperative radiotherapy with or without chemotherapy (TL + PORT/CRT) in T3-T4aN0-N1 disease.…

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