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Rethinking Drug Resistance in Acute Promyelocytic Leukemia: The Regulated Cell Death Network as an Integrative Framework.

Shiyu Lin, Biaohan Qin, Zhexi Ye, Jiaqi Qing, Hui Zhen, Sennan Yang, Xin Jiang, Yiwen Fan, Lemei Zhu, Juan Liu

BiomoleculesSep 21, 2026PMID 42793207doi:10.3390/biom16091375 PMC13604277Journal ArticleReviewpubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

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Drug resistance in acute promyelocytic leukemia (APL) remains clinically challenging despite the success of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) therapy. Existing explanations, including promyelocytic leukemia protein-retinoic acid receptor alpha (PML-RARα) mutations and…

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