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Construction of an Esophageal Cancer Prognostic Model Based on Mitochondrial Energy Metabolism-Related Genes and Mechanism of INHBA in Promoting Malignant Progression via the Smad2/3 Pathway.

Jinping Li, Yi Yao, Huikai Li, Bozong Shao, Enqiang Linghu

BiomoleculesSep 20, 2026PMID 42793200doi:10.3390/biom16091367 PMC13604558Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

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OBJECTIVE: Esophageal cancer (ESCA) has poor prognosis and lacks reliable biomarkers. This study aimed to construct a mitochondrial energy metabolism-related prognostic model and identify key regulatory genes. METHODS: TCGA-ESCA and GSE53625 data were used as training and validation cohorts,…

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