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Safety of laparoscopic surgery without No.253 lymph node dissection for mid and low rectal cancer (SMOOTH): study protocol for a phase III, multicentre randomised controlled trial in China.

Mingguang Zhang, Shuohui Dong, Haitao Zhou, Wei Pei, Zhaoxu Zheng, Qiang Feng, Jianqiang Tang, Zheng Jiang, Jianwei Liang, Qian Liu

BMJ openSep 25, 2026PMID 42790919doi:10.1136/bmjopen-2025-115749 Journal ArticleClinical Trial ProtocolpubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

Abstract

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INTRODUCTION: Total mesorectal excision is currently the standard surgical treatment for rectal cancer; however, the optimal extent of proximal lymph node dissection remains a subject of ongoing debate. The No.253 lymph node is the third station node along the inferior mesenteric artery system.…

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Registered trialsNCT06146946

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