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Exploring MV14 as a nitric oxide-releasing strategy for bladder cancer: From synthesis to in vivo evaluation.

Miriam López, María Varela, Mariana Ingold, María Laura Lavaggi, Martín Breijo, Florencia Fontes, Marcelo Fernández, José Manuel Verdes, Juan Manuel Ramirez-Reyes, Victoria Yozzi, Camila Romero, Rosina Dapueto, Ana Laura Reyes, Manuela Bentura, Eduardo Savio, Paula Céspedes, Karen Perelmuter, Mariela Bollati-Fogolín, Gloria V López, Paola Hernández

European journal of medicinal chemistrySep 22, 2026PMID 42790168doi:10.1016/j.ejmech.2026.119331 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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Bladder cancer remains a significant clinical challenge due to high recurrence rates and limited therapeutic options. Herein, we report the synthesis and biological evaluation of MV14, a nitric oxide-releasing compound with promising antitumor activity against bladder cancer. MV14 reduced cell…

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