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Pantoprazole as a potential repurposed drug targeting the adenosinergic system in esophageal cancer.

Adriana Simioni, Rafael D Weimer, Julia B de Souza, Isadora V Citrini, Julia A da Rosa, Kaline Cardoso, Maria E Delawi, Luis Fsm Timmers, Fernanda B Morrone

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agentsSep 25, 2026PMID 42789078doi:10.1007/s00044-026-03618-2 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260930-000001
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Esophageal cancer remains a major global health burden and is associated with poor prognosis. Adenosine signaling, particularly through CD73 and P1 receptors, contributes to tumor progression and immune modulation. Pantoprazole, a proton pump inhibitor widely used in clinical practice, has recently…

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