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Ruling Out Early Distant Recurrence in Stage III Colon Cancer: A Simple 4-Variable Machine Learning Model with External Validation.

Shih-Feng Huang, Chao-Wen Hsu, Yu-Hsun Chen, Chih-Chien Wu, Yi-Kai Kao

Diseases of the colon and rectumSep 25, 2026PMID 42788791doi:10.1097/DCR.0000000000004456 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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BACKGROUND: Early distant recurrence within 18 months reflects aggressive tumor biology in Stage III colon cancer. Current anatomical staging often fails to capture this biological heterogeneity. OBJECTIVE: To develop and externally validate a simple, pathology-based model for ruling out early…

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