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Elevated miR-103b in exosomes derived from brain-metastatic triple-negative breast cancer cells remodels the brain pre-metastatic niche (PMN).

Li Zhou, Jin Ke, Shanlan Zhang, Sufang Xiao, Hui Zhang, Shan Liu, Li Liu, Mingan Liu, Zuohua Lu, Songguo Zheng

Cancer biology & therapyDec 31, 2026PMID 42788345doi:10.1080/15384047.2026.2725357 PMC13618856Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
Published

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BACKGROUND: Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer with high brain metastatic (BM) potential. Tumor-derived exosomes are implicated as key modulators during the formation of the pre-metastatic niche (PMN). However, the regulation of TNBC-BM-derived exosomes on…

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