Publication
Targeting an ASCL1-WNT11-ERK feed-forward loop to overcome pyrotinib resistance in HER2-positive breast cancer.
Fang Yin, Boxuan Zhou, Yingliang Li, Zide Liu, Chao Zhu, Yu Wang, Chuang Meng, Zhanglin Zhang, Alan Jiang, Wei Liu, Hongfei Liu, Xiaocheng Mao, Hong Tang, Tianmei Fu, Linwei Fan, Chengqi Gao, Kuai Yu, Qi Zeng, Aiping Le
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- PubMed
- Retrieved
- Sep 30, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260930-000001
Abstract
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Pyrotinib resistance remains a therapeutic obstacle in human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC), and tumor-selective strategies to restore drug response are lacking. Here, we identify ASCL1 as a mediator of pyrotinib resistance. ASCL1 was elevated in resistant…
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- cancerMalignant Breast Neoplasmdictionary0.60
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