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An endoplasmic reticulum-enriched nanogel couples ferroptotic tumor damage with macrophage reprogramming for triple-negative breast cancer immunotherapy.

Heying Chen, Yilu Ni, Jiaruo Tang, Yongyuan Ma, Jie Zhang, Jiayu Zhang, Hongyan Sun, Jun Chen, Zhenglin Yang, Dongqing Wang

Bioactive materialsFeb 1, 2027PMID 42787620doi:10.1016/j.bioactmat.2026.09.015 PMC13602404Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
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Triple-negative breast cancer (TNBC) is characterized by severely immunosuppressive tumor microenvironment (TME), which leads to tumor ferroptosis resistance and dominant protumor M2 macrophages, restraining innate-to-adaptive antitumor immune cascade. Herein, an endoplasmic reticulum (ER)-enriched…

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