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Serial serum interleukin-8 trajectories are associated with progression from Helicobacter pylori-associated precancerous lesions to gastric cancer: a prospective longitudinal cohort study.

Atteyat A Semeya, Raafat S A Abdel Hafez, Rasha Elgamal, Abeer Badr, Mahmoud Ibrahim Orabi, Shimaa R Younis, Mahmoud M Morgan, Mahmoud Ahmed Hassan, Mohamed Ramzy Alawy, Amira A A Othman

Gut pathogensSep 23, 2026PMID 42786516doi:10.1186/s13099-026-00876-8 PMC13613814Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

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BACKGROUND: Gastric cancer remains the fourth leading cause of cancer-related mortality worldwide, with delayed diagnosis contributing to poor prognosis. Current biomarkers lack sensitivity for early detection. Interleukin-8 (IL-8), a pro-inflammatory chemokine implicated in H. pylori-associated…

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