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Genomic Characterization of RTK-RAS Pathway Alterations in Juvenile Myelomonocytic Leukemia Through Whole-Exome Sequencing.

Harsh Goel, Ravi Kumar Majhi, Jagdish Prasad Meena, Anita Chopra, Sameer Bakhshi, Lata Singh, Rachna Seth, Bibekananda Kar, Pranay Tanwar, Aditya Kumar Gupta

Medical sciences (Basel, Switzerland)Sep 18, 2026PMID 42783456doi:10.3390/medsci14050583 PMC13609367Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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BACKGROUND/OBJECTIVES: Juvenile myelomonocytic leukemia (JMML) is a rare and very aggressive pediatric myelodysplastic/myeloproliferative neoplasm with molecular heterogeneity and constitutive activation of the RAS signaling pathway. The aim of this study was to identify the mutational landscape,…

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