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Conserved Metastatic Cell States and Spatial Immune Microenvironment Remodeling Define Pancreatic Cancer Liver Metastases.

Ayushi Mandloi, Christina R Larson, Tuan M Tran, Sudharonjon Roy, Ateeq M Khaliq, Yu-Hua Dean Fang, Jace Baines, Richard P Laube, Meet Patel, Christopher Risley, Robert S Welner, Satwik Acharyya, Ashiq Masood, Julienne L Carstens

bioRxiv : the preprint server for biologySep 20, 2026PMID 42779702doi:10.64898/2026.05.27.728281 PMC13596145Journal ArticlePreprintpubmedProvenance
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PubMed
Retrieved
Sep 26, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260926-000001
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BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) mortality is driven largely by liver metastatic disease; however, the malignant cell states and tumor microenvironmental features of PDAC liver metastases remain obscure. METHODS: We developed a transplant model system of matched pancreatic and…

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