Publication
Hepatocytes promote liver metastasis of pancreatic cancer by providing serine.
Koelina Ganguly, Keisuke Yamamoto, Jason Rodencal, Joel Encarnacion-Rosado, Albert S W Sohn, Douglas E Biancur, Elaine Y Lin, Ruohong Wang, Carolina Alcantara Hirsch, Anthony Sorrentino, Elshaddai Z White, Paul M Grandgenett, Michael A Hollingsworth, Miwako Kakiuchi, Richard Possemato, Dafna Bar-Sagi, Mitsuhiro Fujishiro, Alec C Kimmelman
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- PubMed
- Retrieved
- Sep 29, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260929-000001
Abstract
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The liver is the primary site of metastasis in pancreatic ductal adenocarcinoma (PDAC), and liver metastases are a major cause of mortality1,2. Nutrient availability in the metastatic niche influences colonization efficiency; however, the metabolic heterogeneity of disseminated tumour cells can…
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Candidate 1
- cancerMalignant Pancreatic Neoplasmdictionary0.60
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