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Targeting pancreatic cancer with adenoviral vectors equipped with transgenes.

Brett L Roach, Mizuho Sato-Dahlman, Kari Jacobsen, Travis Gates, Ryan Shanley, Ingunn M Stromnes, Masato Yamamoto

Molecular cancer therapeuticsSep 24, 2026PMID 42778197doi:10.1158/1535-7163.MCT-25-1231 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, and current therapeutics provide limited benefits to patients. Desmoplasia and the highly immunosuppressive tumor microenvironment (TME) play a huge role in PDAC being elusive to current therapeutics. Here, we strategically…

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