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Epitranscriptomic stabilization of PGRMC1 by the METTL3-IGF2BP1 axis promotes ovarian cancer progression.

Yue Zhao, Yinxing Zhu, Dejia Chen, Xiaochen Shi, Jinglin Wen, Zhiqiang Wang, Yiming Liu, Ge Lou

Cellular signallingSep 23, 2026PMID 42777928doi:10.1016/j.cellsig.2026.112887 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260930-000001
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Ovarian cancer (OV) remains one of the most lethal gynecological malignancies, with limited effective early detection strategies and therapeutic options. Despite advances in platinum-based chemotherapy and targeted therapies, including PARP inhibitors and immune checkpoint inhibitors, treatment…

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