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Single-cell landscape reveals PLPP2 upregulation underlying radiotherapy resistance and immune microenvironment remodeling in pancreatic cancer.

Yifei Wang, Parhat Kaysar, Yijian Ma, Ziyun Liu, Yuxi Han, Weishuai Liu, Huifang Pang, Yaoyao Zhou

Translational oncologySep 23, 2026PMID 42777648doi:10.1016/j.tranon.2026.103054 Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

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The main purpose of this study was to investigate the molecular mechanisms underlying radiotherapy resistance in pancreatic cancer by integrating single-cell transcriptomic analysis with multicenter clinical cohorts. Using machine learning algorithms and genomic data, we identified key genes…

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