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Total neoadjuvant therapy for organ preservation in rectal cancer: Interpreting heterogeneous trial evidence.

Cédric Schraepen, André D'Hoore, Ellen Coeckelberghs, Gabriele Bislenghi, Karin Haustermans, Jelle Verhoeven, Gertjan Rasschaert, Jeroen Dekervel, Sabine Tejpar, Raphaela Dresen, Valérie Broeckhoven, Albert Wolthuis

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologySep 18, 2026PMID 42777644doi:10.1016/j.ejso.2026.112129 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 30, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260930-000001
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Total neoadjuvant therapy (TNT) in locally advanced rectal cancer (LARC) aims to improve disease control and increase opportunities for organ preservation. However, interpretation and comparison of outcomes across TNT trials remain challenging due to heterogeneity in study design, treatment…

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