Publication
E2F3 amplification primes bladder cancer cells for premature mitosis.
Kathryn A Wierenga, Isabel S Nieland, Qingwu Liu, Pepijn R J Rakers, Anita van den Heuvel, Mara Pateli, Richard W Wubbolts, Frank M Riemers, Saskia C van Essen-Dorresteijn, Elsbeth A van Liere, Bart Westendorp
- Source
- PubMed
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-PUBMED-20260929-000001
Abstract
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The E2F-RB pathway controls the G1/S checkpoint, and tumors often bypass it through RB1 or CDKN2A loss. Unlike these lesions, E2F3 amplification drives persistent excessive E2F-dependent transcription through S and G2 phases. This oncogene is frequently amplified in for example bladder cancer, but…
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Candidate 1
- cancerMalignant Bladder Neoplasmdictionary0.60
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