Publication
RAF1 scaffold integrity shapes chemogenetic degradation outcomes in KRAS-driven lung cancer models.
Laura de-la-Puente-Ovejero, Ana Domostegui, Inés María García-Pérez, Gonzalo Aizpurua, Lucía Lomba-Riego, Pilar Ximenez-Embún, Cristina Mayor-Ruiz, Mariano Barbacid, Sara García-Alonso
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- PubMed
- Retrieved
- Sep 29, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260929-000001
Abstract
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Scaffold integrity is essential for the activity of proteins that function through protein-protein interactions rather than catalytic output. RAF1 exemplifies this duality: although it is a bona fide kinase and a core component of the MAPK cascade, its tumor-promoting role is largely…
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- cancerMalignant Lung Neoplasmdictionary0.60
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