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Modeling Liver Cancer Molecular and Histological Features by CRISPR Editing of Porcine Hepatocytes.

Lobna Elkhadragy, Olayinka G David, Caitlyn C Castillo, Luke N Redlon, Luke R Jordan, Nusrat Khan, Hannah Liu, Isadora Andre Rosa Lopes, Yanqiong Zhou, Hiroaki Kanzaki, Yujin Hoshida, Jonathan P Samuelson, Amaia Lujambio, Lawrence B Schook, Grace Guzman, Kyle M Schachtschneider, Ron C Gaba

JHEP reports : innovation in hepatologySep 22, 2026PMID 42772422doi:10.1016/j.jhepr.2026.102042 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 29, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260929-000001
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BACKGROUND: /Aims: Hepatocellular carcinoma (HCC) is an aggressive disease with limited response to available therapies. Progress in therapeutic development has been hampered by the lack of preclinical models that recapitulate human HCC and support evaluation of multimodal therapies. Here, we…

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