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Bioengineered extracellular vesicles integrating anti-EphA2 recognition and oxaliplatin delivery for pancreatic cancer therapy.

Shi-Wei Chao, Wan-Chi Tsai, Yung-Han Chang, Shan-Jou Chen, Chia-Tse Li, Jo-Han Fan, Bo-Cheng Huang, Shih-Ting Hong, Hong-Ren Wang, Yu-Ting Huang, Ming-Yii Huang, Chih-Hung Chuang

Drug deliveryDec 31, 2026PMID 42771518doi:10.1080/10717544.2026.2728215 PMC13600275Journal ArticlepubmedProvenance
Source
PubMed
Retrieved
Sep 29, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260929-000001
Published

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Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors due to its dense desmoplastic stroma, poor vascular perfusion, and the limited intratumoral delivery of chemotherapeutic agents such as oxaliplatin (OXA). Extracellular vesicles (EVs) offer a biocompatible platform…

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