Publication
Inflammatory memory inactivates AMPK-stimulated DDR1 degradation to enable pancreatic cancer growth.
Fei Yang, Bo Lin, Yongkang Yuan, Zihang Yuan, Xiaohong Pu, Chunlan Wang, Da Zhang, Yang Yang, Kosuke Watari, Rongkui Luo, Jian Zhou, Xinrong Yang, Beicheng Sun, Michael Karin, Hua Su
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- PubMed
- Retrieved
- Sep 29, 2026
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- normalized (units and labels harmonized; values unchanged)
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- ING-PUBMED-20260929-000001
Abstract
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Inflammation and stromal remodeling control pancreatic ductal adenocarcinoma (PDAC), but whether and how these cues are integrated at the molecular level remains unclear. Here, we identify a metabolic checkpoint that controls the stability of the collagen receptor discoidin domain receptor 1…
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- cancerMalignant Pancreatic Neoplasmdictionary0.60
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