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Th1-biased iNKT cell agonist-loaded liposomal peptide vaccines synergize with a PD-L1 inhibitor to boost immunotherapy against gastric cancer.

Jing-Jing Du, Lei Chen, Rong-Ling Liu, Yong-Heng Niu, Xian-Chen Yang, Shi-Hao Zhou, Jun Guo, Yu Wen, Zhen-Hong Su, Ru-Yan Zhang

Chemical communications (Cambridge, England)Sep 22, 2026PMID 42770294doi:10.1039/d6cc03949a Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 26, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260926-000001
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We covalently conjugated the Th epitope DT331-345 with the MG3 peptide and co-encapsulated the conjugate with an iNKT cell agonist into liposomes to prepare a vaccine. The DT-MG3/GCS-11 formulation elicited strong antibody responses and promoted T-cell responses. Notably, its combination with PD-L1…

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