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GMPS drives pancreatic cancer progression via suppressing DNA damage, STING activation and cellular senescence.

Yangyi Li, Zifeng Zhang, Dingru Li, Cong Zhou, Yueyue Chen, Chunbin Zhu, Jianhui Yang, Rong Tang, Wei Wang, Xianjun Yu, Jin Xu

Translational oncologySep 21, 2026PMID 42767098doi:10.1016/j.tranon.2026.103044 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 26, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-PUBMED-20260926-000001
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BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy with scarce viable treatment targets. Metabolic rewiring is a typical characteristic of PDAC, but the roles of many metabolic enzymes remain poorly defined. METHODS: We integrated DepMap and TCGA data to…

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