Publication
Targeted BRD4 degradation by multivalent dendrimer-based PROTAC and its combined effects with chemotherapy on colon cancer.
Ramalingam Sharmila, Weng Chi Iong, I-Lin Lu, Arjun Sabu, Chun-Liang Lo, Mina Ming-Yin Shen, Hsin-Cheng Chiu
BiomaterialsSep 17, 2026PMID 42766962doi:10.1016/j.biomaterials.2026.124634 Journal ArticlepubmedProvenance
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- Sep 29, 2026
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- ING-PUBMED-20260929-000001
Abstract
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Chemoresistance, often driven by aberrant transcriptional and epigenetic mechanisms, remains a significant barrier to effective colon cancer therapy. This study introduces a dendrimer-based proteolysis-targeting chimera (PROTAC) system, JTP, generated by conjugation of polyamidoamine (PAMAM-G4)…
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- cancerMalignant Colon Neoplasmdictionary0.60
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