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Longitudinal Analysis of Matched Patient Biospecimens Reveals Neural Reprogramming of Cancer-Associated Fibroblasts Following Chemotherapy in Pancreatic Cancer.

Aylin Z Henstridge, Peter A Azorsa, Nandini Arya, Ahmed M Elhossiny, Padma Kadiyala, Molly Goldwasser, Georgina Branch, Vaibhav Sahai, Nicole Peterson, Jorge D Machicado, Richard S Kwon, Allison R Schulman, Erik-Jan Wamsteker, George M Philips, Stacy B Menees, Jonathan Y Xia, Tara L Hogenson, Arvind Rao, Jiaqi Shi, Timothy L Frankel, Filip Bednar, Marina Pasca di Magliano, Costas A Lyssiotis, Mark J Truty, Martin E Fernandez-Zapico, Eileen S Carpenter

Cancer researchSep 21, 2026PMID 42765602doi:10.1158/0008-5472.CAN-26-0823 Journal ArticlepubmedProvenance
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PubMed
Retrieved
Sep 26, 2026
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normalized (units and labels harmonized; values unchanged)
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ING-PUBMED-20260926-000001
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Pancreatic ductal adenocarcinoma (PDAC), the most common subtype of pancreatic cancer, is a deadly disease with a complex tumor microenvironment (TME). Cytotoxic combination chemotherapy treatments are the mainstay of PDAC therapy, but patients rapidly develop chemoresistance, highlighting the need…

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